Insulin-like growth factor II/cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition.
نویسنده
چکیده
I36 1 1 Chao, H. H.-J., Waheed, A., Polhmann, R., Hille, A. and von Figura, K. (1990) EMBO J. 9, 3507-3513 12 Ma, Z., Grubb, J. H. and Sly, W. S. (1991) J. Biol. Chem. 266, 10589-10595 13 Johnson, K. F. and Kornfeld, S. (1992) J. Biol. Chem. 267, 17110-17113 14 Ludwig, T., Ruther, U., Metzger, R., Copeland, N. G., Jenkins, N. A., Lobel, P. and Hoflack, B. (1992) J. Biol. Chem. 267, 1221 1-12219 15 Ludwig, T., Ovitt, C., Bauer, U., Hollinshead, M., Remmler, J., Lobel, P., Ruther, U. and Hoflack, B.
منابع مشابه
Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice.
Two proteins have been implicated in the mannose 6-phosphate-dependent transport of lysosomal enzymes to lysosomes: the 300kDa cation-independent and the 46kDa cation-dependent mannose 6-phosphate receptors (CI- and CD-MPRs). The mammalian CI-MPR also mediates endocytosis and clearance of insulin-like growth factor II (IGF-II). Mutant mice that lack the CD-MPR are viable, mice that lack the CI-...
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We have cloned and sequenced the full-length cDNA for the human cation-independent mannose 6-phosphate receptor from four overlapping clones. The 9104-nucleotide sequence contains 7473 nucleotides which encode a protein of 2491 amino acids. The amino acid sequence includes a putative signal sequence of 40 amino acids, an extracytoplasmic domain consisting of 15 homologous repeat sequences of 13...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 24 1 شماره
صفحات -
تاریخ انتشار 1996